Immunolog jobb i Lund

About Asgard Therapeutics
Asgard Therapeutics is a privately held biotech company pioneering in vivo direct cell reprogramming for cancer immunotherapy, backed by Johnson & Johnson Innovation – JJDC, Inc., RV Invest, Novo Holdings, Boehringer Ingelheim Venture Fund, and Industrifonden. Our lead candidate, AT-108, is a first-in-class gene therapy that reprograms tumor cells into antigen-presenting dendritic cells (cDC1), triggering a personalized and potent anti-tumor immune response.

Position Overview
The ideal in vivo scientist candidate will have a background in immuno-oncology and hands-on experience in in vivo research. The role will involve executing in vivo and in vitro experiments, analyzing data, troubleshooting technical issues, and contributing to ongoing projects. Strong interpersonal, verbal, and written communication skills are required. Experimental rigor, scientific curiosity, and the ability to work in a fast-paced environment, adapting to evolving priorities, are musts.

Key responsibilities
Conduct in vivo studies using syngeneic and CDX mouse models to evaluate biodistribution, therapeutic efficacy, and safety.
Perform immunological assays including flow cytometry, ELISpot, T-cell co-culture assays, and cytokine profiling.
Analyze and summarize data in reports and communicate findings to Asgard's R&D and executive leadership team.
Assist in experiment planning, execution, and documentation according to standard protocols.


Qualifications
PhD degree in Immunology, Cancer Biology, Biomedicine, or a related life science discipline.
Hands-on experience with in vivo mouse work in an academic or industry setting.
Basic understanding of cancer immunotherapies is critical, knowledge of dendritic cell and T cell biology is a plus.
Experience in tumor biology-related in vitro assays, including multi-color flow cytometry for ELISpot and T-cell cytotoxicity assays.
Experience with small molecule and viral vectors handling and their in vivo administration is a plus.
Felasa B or equivalent animal handling certification is required.
Strong organizational skills and ability to work in a team-oriented environment.
Good written and verbal communication skills in English.


Literature
Ascic E, at al. In vivo dendritic cell reprogramming for cancer immunotherapy. Science 386, eadn9083 (2024). DOI:10.1126/science.adn9083
Zimmermannova O, et al. Restoring Tumor Immunogenicity with Dendritic Cell Reprogramming. Science Immunology 8, eadd4817 (2023). DOI: 10.1126/sciimmunol.add4817


Application
Please email your CV, cover letter and contact information for two references to careers@asgardthx.com to apply. Asgard will review applications on a rolling basis and only shortlisted candidates will be contacted.

About the position
Are you Idogen’s next Senior Research Scientist? Do you have expertise and experience in Immunology/transplantation immunology/ human cell biology?

Would you like to apply your expertise in a company that pushes the boundaries of science and turns ideas into life changing therapies? Join Idogen and become a key player in leading, designing, and conducting R&D projects within the immunology area.

Idogen develops tolerogenic cell therapies to prevent the patient’s immune system from attacking biological agents, transplanted organs or the body’s own cells or tissues. The company is on a growth journey and has in March 2022 received Swedish MPA approval to start a Clinical Trial within the indication Hemophilia A.

As a Sr. Scientist you will be part of the R&D team of 9 people, reporting to the Chief Scientific Officer.

Responsibilities
• Lead, design, and conduct research and development projects within the immunology area
• Plan, perform, and report experiments, including primary cell purification and cultures, cell- based assays and multicolour flow cytometry-based and Luminex immunophenotyping
• Work closely with CRO within non-clinical area
• Actively apply knowledge gained from literature, conferences and previous working experience on novel concept and assay development

Your profile
• Ph.D. within immunology, preferably within transplantation
• Work experience in related scientific discipline and/or Post Doc. experiences
• Experience in being the lead of a project team, from research to development phase, and preferably clinical phase
• Expertise in a wide range of cell-based assays, including primary cell purification and cultures and multicolour flow cytometry
• Experienced in working according to GxP and EMA/FDA guidelines
• Ability to independently design, coordinate, perform, analyse, and report experiments, always with quality in mind
• Ability to conduct in vivo studies and experiences to work with CROs
• Excellent communication skills, both orally and in writing
• As a person you are highly motivated, quality minded and enjoy working in a team-oriented environment
• Cell therapy experience from a small start-up company is a merit

About the organisation
Idogen is a Swedish biotechnology company based in Lund, listed on the Nasdaq First North Growth Market. Idogen revolutionises the treatment of several disorders in which the body’s immune system does not function as it should, and for which there is a major unmet medical need – such as in autoimmune diseases, organ transplant rejection and in patients who have developed anti-drug antibodies.

QRIOS Life Science & Engineering is supporting Idogen on this recruitment. We are a recruitment and consulting company that is strongly inspired by those who never stop looking for new solutions. As we say, QRIOS MINDS GO FURTHER

We are interviewing candidates on an ongoing basis and welcome your application via the application link today.

BioInvent International AB (OMXS: BINV) is a clinical stage company focused on the development of novel, first-in-class immuno-modulatory antibodies for the treatment of cancer, addressing the need for novel treatment options that have the potential to significantly improve patient outcomes. Our powerful discovery engine is based on our validated, proprietary F.I.R.S.T™ technology and our proprietary n-CoDeR® antibody library to simultaneously identify targets and antibodies that bind to these targets, generating many promising new drug candidates to fuel the Company’s proprietary product pipeline as well as for licensing and partnering purposes. More information is available at www.bioinvent.com.
The BioInvent team covers all aspects of drug development, including discovery, preclinical and translational research, manufacturing, and clinical development.
Together we are creating the exciting future of BioInvent, and we welcome you to be part of it – as our Director Regulatory Affairs.
Key Responsibilities
The Head of Regulatory Affairs is responsible for developing and executing global regulatory strategies aimed at identifying and implementing the most efficient regulatory pathways for BioInvent’s current and future drug development programs.
The responsibilities of the position include, but are not limited to:
Developing and formulating BioInvent’s regulatory strategy and policy, ensuring that product manufacturing (CMC), pre-clinical and clinical development plans comply with all applicable regulatory requirements (e.g., global development plan, TPP).
Overseeing the planning and preparation of regulatory submissions to pursue expedited review to facilitate development of BioInvent’s drugs (e.g., IND/CTA, scientific advice, orphan drug designation, fast track designation, breakthrough designation, PRIME) and maintaining these.
Maintaining a high-quality network of service providers and consultants to bring expert critical thinking about regulatory strategy.
Acting as an internal resource for regulatory input on pre-clinical, clinical and product development (CMC) policies.
Planning, coordination and preparation of communications and interactions with regulatory agencies (e.g., scientific advice meetings, pre-IND, IND meetings) including leading the preparation of briefing documents and attending the meetings.
Supporting due diligence and partnering activities, as needed.
Analyzing and communicating current regulatory guidance and regulations, as well as industry and regulatory agency best practices and trends, to keep company informed on any relevant changes in the regulatory landscape.
Contributing to corporate development strategies and implementation of a risk-based clinical Quality Management System.
Performing all duties in keeping with BioInvent’s core values, policies, and all applicable regulations.

Requirements
At least 10 years regulatory affairs experience in the biotech or pharmaceutical industry, preferably experience of early phase studies in oncology and /or hematology drug development. Experience with immunotherapies and monoclonal antibodies would be an advantage.
Detailed knowledgeable of European, US FDA pharmaceutical regulations and guidance, drug development process (in addition, knowledge of Chinese environment would be an advantage)
Proven ability to think strategically; managed and solved challenging regulatory issues.
Superior communication skills in cross-cultural environments
Ability to manage complexity and uncertainty.
Excellent business judgment, problem solving skills.
Enjoy creating and participating in an efficient cross functional working environment.
Be flexible, think creatively, and be willing to undertake different approaches.
Practical experience in project management and leadership.
Proficient in MS Word, Excel, Power Point, Outlook, MS Project.
Proficient in written and spoken English.
Excellent presenting skills.

Qualifications
Educated to BA/BSc level in relevant life science discipline.
Desirable: Masters/ PhD/ PharmD in related area of discipline (sciences, clinical, business, project management)


Personal Profile
We are looking for a driven, structured, self-motivated and responsible person, who easily collaborates and communicates with others both verbally and in writing. You have excellent problem solving, and negotiation skills and you enjoy creating efficient working methods and contributing with your experience to ensure continuous improvements.
Personal suitability is of great importance and we believe that you are efficient, have a strong commitment and ability to make things happen. You understand the importance of achieving results, keeping deadlines and to secure high quality within your work. You are enthusiastic and enjoy creating results and achieving goals both individually and together with your teams.
To summarize, BioInvent has several value driving factors in place with great potential for the future. If you match the described profile and would like to contribute to important cancer research as a part of BioInvent and our exciting future, you are welcome to apply for the position!
Location
The position is office based in Lund. However, the position may also offer a flexible working arrangement.
Application
Please send your application (CV and personal letter) through our website https://careers.bioinvent.com/
Interviews will be held continuously which means the positions can be filled before deadline. Please make sure to send in your application as soon as possible, at the latest 17 April 2021.
BioInvent has a collective agreement and contact persons for the Unions are:
Fredrik Wiberg, Akademikerföreningen and Jenny Nilsson, Unionenklubben

Huvudsakliga arbetsuppgifter
Tjänsten innebär att du jobbar på BioInvents forskningsavdelning, i ett translationellt team dvs i gränslandet mellan pre-klinik och klinik.
Tjänsten innefattar experimentellt arbete med uppsättning och genomförande av assays för att studera biomarkörer i våra kliniska studier och i in vivo modeller med hjälp av immunohistokemi eller immunofluorescence. Ytterligare pre-kliniska och klinikrelevanta assays för att analysera t.ex. farmakokinetik (PK) och immunogenicitet (anti-drug-antibodies, ADA) ingår i denna tjänst, liksom arbete in vivo och in vitro med celler (cellinjer och primära celler) som utgör en grundpelare i detta arbete. Dokumentation, information och kommunikation, både internt och externt, är en del av ditt arbete.
Profil
Du har relevant akademisk utbildning, gärna disputerad inom cellbiologi/immunologi, och erfarenhet av immunologiska frågeställningar.
Du har även dokumenterade praktiska färdigheter av arbete in vivo och in vitro med celler och relevanta metoder såsom immunohistokemi eller immunofluorescence, ELISA och MSD. Erfarenhet av translationellt arbete i gränslandet mellan preklinik och klinik är meriterande. Koordinerande erfarenhet gentemot samarbetspartners och CROer, samt erfarenhet av (antikropps)läkemedelsutveckling, är likaså meriterande men inget krav.
Som person är du noggrann, strukturerad och ansvarsfull men samtidigt effektiv, drivande och kreativ. Personlig lämplighet är av stor betydelse och vi tror att du har en positiv attityd, ett starkt engagemang och en god samarbetsförmåga. Du förstår vikten av att uppnå resultat, hålla deadlines och säkerställa hög kvalitet i ditt arbete. Du är entusiastisk, har en vilja att lära dig nya saker och tycker om att skapa resultat och uppnå mål både individuellt och tillsammans med teamet.
Då du kommer jobba i gränslandet mellan intern-, extern-, preklinisk- och klinisk forskning, är en stark förmåga att kommunicera i tal och skrift på svenska och engelska, samt att dokumentera, organisera och jobba flexibelt mellan högkompetenta team avgörande.
Övrigt
Tjänsten är en heltidstjänst baserad i Lund.
Ansökan
Vill du vara med och bidra till cancerforskningen som en del av BioInvent och vår spännande framtid och du dessutom passar in på beskrivningen ovan så tveka inte att skicka in din ansökan till oss!
Välkommen med din ansökan (CV och personligt brev) via https://careers.bioinvent.com/ senast den 1 juli 2020. Vi arbetar med löpande urval och intervjuer vilket innebär att tjänsten kan komma att tillsättas tidigare än sista ansökningsdatum så skicka gärna din ansökan så snart som möjligt.


BioInvent är medlemmar i Innovations- och kemiarbetsgivarna och följer tjänstemannaavtalet, våra fackliga kontaktpersoner är:
Fredrik Wiberg, Akademikerföreningen & Jenny Nilsson, Unionenklubben,

Lunds universitet grundades 1666 och rankas återkommande som ett av världens 100 främsta lärosäten. Här finns 40 000 studenter och 7 400 medarbetare i Lund, Helsingborg och Malmö. Vi förenas i vår strävan att förstå, förklara och förbättra vår värld och människors villkor.


Lunds Tekniska Högskola, LTH, är en teknisk fakultet inom Lunds universitet med forskning av hög internationell klass och stora satsningar på pedagogisk mångfald.



Särskild ämnesbeskrivning Forskningsområdet är masspektrometribaserad proteomik, med speciellt fokus på anrikning av modifierade proteiner med olika affinitetsmetoder.

Arbetsuppgifter Anställningen innefattar framför allt handhavande av avancerad vätskekromatografi-masspektrometri (LC-MS)-utrustning, samt bearbetning av prover för denna. Detta inkluderar olika affinitetsmetoder, framförallt anrikning av fosfoproteiner och andra posttranslationellt modifierade proteiner. Anställningen innebär även diskussioner med samarbetspartners kring användningen av LC-MS i forskningsprojekt.

Krav För anställningen krävs:

- Avlagd doktorsexamen inom masspektrometribaserad proteomik.
- Gedigen praktisk forskningserfarenhet inom kvantitativ LC-MS-baserad proteomik, inklusive handhavande av högupplöst LC-MS-utrustning.
- Erfarenhet av provberedning för masspektrometri.
- Dokumenterad erfarenhet av anrikning av fosfoproteiner och andra posttranslationellt modifierade proteiner
- Erfarenhet av processning och analys av kvantitativ LC-MS-data
- Erfarenhet av användning av fosfoproteomik inom medicinska forskningsprojekt
- Goda kunskaper i engelska, i tal och skrift

Vi kommer att lägga stor vikt vid personlig lämplighet. Hänsyn kommer att tas till ex. god samarbetsförmåga, driv och självständighet samt hur den sökande genom sin erfarenhet och kompetens bedöms komplettera och stärka det administrativa arbetet inom avdelningen/institutionen.

Villkor Tidsbegränsad anställning, vikariat 100 %, fr.o.m. 2018-08-01 - 2019-07-31.

Instruktioner för ansökan Ansökan bör innehålla personligt brev med motivering till varför du är intresserad av anställningen och på vilket sätt anställningen matchar dina meriter. Ansökan bör även innehålla CV, examensbevis eller motsvarande samt övrigt som du önskar åberopa (kopior av betyg, uppgifter till referenser, rekommendationsbrev etc.).

 

 

 

 







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Lunds universitet välkomnar sökande med olika bakgrund och erfarenheter. Vi ser jämställdhet och mångfald som en styrka och tillgång. Välkommen med din ansökan! Vi undanber oss alla kontakter från annonsförsäljare, rekryterings- och bemanningsföretag på grund av statliga upphandlingsregler.