Lund: Scientist/Senior Scientist In vitro Immuno-Oncology

About Asgard Therapeutics
Asgard Therapeutics is a privately held biotech company pioneering in vivo direct cell reprogramming for cancer immunotherapy, backed by Johnson & Johnson Innovation – JJDC, Inc., RV Invest, Novo Holdings, Boehringer Ingelheim Venture Fund, and Industrifonden. Our lead candidate, AT-108, is a first-in-class gene therapy that reprograms tumor cells into antigen-presenting dendritic cells (cDC1), triggering a personalized and potent anti-tumor immune response.

Position Overview
The ideal in vivo scientist candidate will have a background in immuno-oncology and hands-on experience in in vivo research. The role will involve executing in vivo and in vitro experiments, analyzing data, troubleshooting technical issues, and contributing to ongoing projects. Strong interpersonal, verbal, and written communication skills are required. Experimental rigor, scientific curiosity, and the ability to work in a fast-paced environment, adapting to evolving priorities, are musts.

Key responsibilities
Conduct in vivo studies using syngeneic and CDX mouse models to evaluate biodistribution, therapeutic efficacy, and safety.
Perform immunological assays including flow cytometry, ELISpot, T-cell co-culture assays, and cytokine profiling.
Analyze and summarize data in reports and communicate findings to Asgard's R&D and executive leadership team.
Assist in experiment planning, execution, and documentation according to standard protocols.


Qualifications
PhD degree in Immunology, Cancer Biology, Biomedicine, or a related life science discipline.
Hands-on experience with in vivo mouse work in an academic or industry setting.
Basic understanding of cancer immunotherapies is critical, knowledge of dendritic cell and T cell biology is a plus.
Experience in tumor biology-related in vitro assays, including multi-color flow cytometry for ELISpot and T-cell cytotoxicity assays.
Experience with small molecule and viral vectors handling and their in vivo administration is a plus.
Felasa B or equivalent animal handling certification is required.
Strong organizational skills and ability to work in a team-oriented environment.
Good written and verbal communication skills in English.


Literature
Ascic E, at al. In vivo dendritic cell reprogramming for cancer immunotherapy. Science 386, eadn9083 (2024). DOI:10.1126/science.adn9083
Zimmermannova O, et al. Restoring Tumor Immunogenicity with Dendritic Cell Reprogramming. Science Immunology 8, eadd4817 (2023). DOI: 10.1126/sciimmunol.add4817


Application
Please email your CV, cover letter and contact information for two references to careers@asgardthx.com to apply. Asgard will review applications on a rolling basis and only shortlisted candidates will be contacted.

About the position
Are you Idogen’s next Senior Research Scientist? Do you have expertise and experience in Immunology/transplantation immunology/ human cell biology?

Would you like to apply your expertise in a company that pushes the boundaries of science and turns ideas into life changing therapies? Join Idogen and become a key player in leading, designing, and conducting R&D projects within the immunology area.

Idogen develops tolerogenic cell therapies to prevent the patient’s immune system from attacking biological agents, transplanted organs or the body’s own cells or tissues. The company is on a growth journey and has in March 2022 received Swedish MPA approval to start a Clinical Trial within the indication Hemophilia A.

As a Sr. Scientist you will be part of the R&D team of 9 people, reporting to the Chief Scientific Officer.

Responsibilities
• Lead, design, and conduct research and development projects within the immunology area
• Plan, perform, and report experiments, including primary cell purification and cultures, cell- based assays and multicolour flow cytometry-based and Luminex immunophenotyping
• Work closely with CRO within non-clinical area
• Actively apply knowledge gained from literature, conferences and previous working experience on novel concept and assay development

Your profile
• Ph.D. within immunology, preferably within transplantation
• Work experience in related scientific discipline and/or Post Doc. experiences
• Experience in being the lead of a project team, from research to development phase, and preferably clinical phase
• Expertise in a wide range of cell-based assays, including primary cell purification and cultures and multicolour flow cytometry
• Experienced in working according to GxP and EMA/FDA guidelines
• Ability to independently design, coordinate, perform, analyse, and report experiments, always with quality in mind
• Ability to conduct in vivo studies and experiences to work with CROs
• Excellent communication skills, both orally and in writing
• As a person you are highly motivated, quality minded and enjoy working in a team-oriented environment
• Cell therapy experience from a small start-up company is a merit

About the organisation
Idogen is a Swedish biotechnology company based in Lund, listed on the Nasdaq First North Growth Market. Idogen revolutionises the treatment of several disorders in which the body’s immune system does not function as it should, and for which there is a major unmet medical need – such as in autoimmune diseases, organ transplant rejection and in patients who have developed anti-drug antibodies.

QRIOS Life Science & Engineering is supporting Idogen on this recruitment. We are a recruitment and consulting company that is strongly inspired by those who never stop looking for new solutions. As we say, QRIOS MINDS GO FURTHER

We are interviewing candidates on an ongoing basis and welcome your application via the application link today.

About Asgard Therapeutics
Asgard Therapeutics is a privately held biotech company pioneering in vivo direct cell reprogramming for cancer immunotherapy, backed by Johnson & Johnson Innovation – JJDC, Inc., RV Invest, Novo Holdings, Boehringer Ingelheim Venture Fund, and Industrifonden. Our lead candidate, AT-108, is a first-in-class gene therapy that reprograms tumor cells into antigen-presenting dendritic cells (cDC1), triggering a personalized and potent anti-tumor immune response.

Position Overview
The ideal in vivo scientist candidate will have a background in immuno-oncology and hands-on experience in in vivo research. The role will involve executing in vivo and in vitro experiments, analyzing data, troubleshooting technical issues, and contributing to ongoing projects. Strong interpersonal, verbal, and written communication skills are required. Experimental rigor, scientific curiosity, and the ability to work in a fast-paced environment, adapting to evolving priorities, are musts.

Key responsibilities
Conduct in vivo studies using syngeneic and CDX mouse models to evaluate biodistribution, therapeutic efficacy, and safety.
Perform immunological assays including flow cytometry, ELISpot, T-cell co-culture assays, and cytokine profiling.
Analyze and summarize data in reports and communicate findings to Asgard's R&D and executive leadership team.
Assist in experiment planning, execution, and documentation according to standard protocols.


Qualifications
PhD degree in Immunology, Cancer Biology, Biomedicine, or a related life science discipline.
Hands-on experience with in vivo mouse work in an academic or industry setting.
Basic understanding of cancer immunotherapies is critical, knowledge of dendritic cell and T cell biology is a plus.
Experience in tumor biology-related in vitro assays, including multi-color flow cytometry for ELISpot and T-cell cytotoxicity assays.
Experience with small molecule and viral vectors handling and their in vivo administration is a plus.
Felasa B or equivalent animal handling certification is required.
Strong organizational skills and ability to work in a team-oriented environment.
Good written and verbal communication skills in English.


Literature
Ascic E, at al. In vivo dendritic cell reprogramming for cancer immunotherapy. Science 386, eadn9083 (2024). DOI:10.1126/science.adn9083
Zimmermannova O, et al. Restoring Tumor Immunogenicity with Dendritic Cell Reprogramming. Science Immunology 8, eadd4817 (2023). DOI: 10.1126/sciimmunol.add4817


Application
Please email your CV, cover letter and contact information for two references to careers@asgardthx.com to apply. Asgard will review applications on a rolling basis and only shortlisted candidates will be contacted.

Asgard Therapeutics AB, Lund, Sweden
Asgard Therapeutics is a spin-off from Lund University, Sweden, aiming to advance cancer immunotherapies by harnessing direct cell fate reprogramming technologies. Our lead program, AT-108, is a adenovirus-based gene therapy that reprograms cancer cells into antigen-presenting conventional type 1 dendritic cells (cDC1s), unleashing the immune system against cancer. Asgard is expanding its multidisciplinary team that understands the value and opportunities of working in a startup based in a unique platform technology. We are looking for candidates who are creative and passionate about making a contribution to the cancer immunotherapy field and improve patients’ lives.
Position Overview
We are seeking a highly enthusiastic and innovative Scientist/Senior Scientist searching for an opportunity to help building an early-stage company and contribute to the development of next generation cancer immunotherapies.
The successful candidate should have the ability to design experiments autonomously, analyze complex data, troubleshoot technical issues, and supervise junior staff. Strong interpersonal, verbal, and written communication skills are required. Experimental rigor, scientific curiosity, and ability to work in a fast-paced environment, adapting to evolving priorities are musts. The position will be lab-based and research activities will be performed in collaboration with the Cell Reprogramming in Hematopoiesis and Immunity Lab at Lund University (www.pereiralab.com) in the context of the EIC Pathfinder project ” RESYNC– Functional chemical reprogramming of cancer cells to induce antitumor immunity“. The RESYNC project aims to use small molecules to reprogram cancer cells into cDC1s in vivo after systemic administration of tumor-targeted nanoparticles.
Profile
Scientist/Senior Scientist with background in tumor immunology to work in the experimental validation of in vivo cDC1 reprogramming induced by AT-108 together with cDC1-promoting small molecules and exclusively mediated by small molecules. The candidate will focus on both efficacy and safety studies in syngeneic and CDX mouse models. The ideal candidate should have a Ph.D. degree in an immunology-related field with relevant in vitro and in vivo laboratory experience in academia or biotech industry.
Responsibilities
Evaluate efficacy of AT-108 in combination with small molecules, or cocktails of cDC1-inducing small molecules in animal models.
Develop methods to characterize the immune response induced by in vivo cDC1 reprogramming, including multi-color flow cytometry, fluorescence-activated cell sorting, T cell co-culture systems, MHC/peptide tetramer analysis, ELISpot, among other immunoassays.
Manage the RESYNC project from Asgard’s side, ensuring that resources are efficiently allocated. Design, plan, and execute scientific experiments autonomously in line with the Company/RESYNC Project goals within designated timelines.
Collect and document primary data to maintain up to date records, including electronic notebook and project reports.
Analyze, summarize data in reports and communicate data to Asgard’s R&D and executive leadership team.

Qualifications
PhD in Immunology, Cancer Biology, Biology or related field, with 0-5 years of post-graduation experience in academic or industrial environment.
Demonstrated knowledge of cancer immunotherapies, including experience in developing relevant in vivo immuno-oncology models (syngeneic and CDX tumor models) to understand mechanism of action underlying preclinical efficacy of cancer therapies.
Preferred qualifications include a background in dendritic cell biology and expertise in antigen presentation mechanisms, with a favorable consideration for candidates with knowledge in T cell biology.
Experience in the development and application of tumor biology-related in vitro assays, including multi-color flow cytometry for immune profiling, MHC/peptide tetramer, ELISpot and T-cell cytotoxicity assays. Experience with TCR sequencing and MHC peptidomics is a plus.
Experience with small molecule handling and their in vivo administration is a plus.
Felasa B certification.

Literature
Ascic E, Åkerström F, Nair MS, Rosa A, Kurochkin I, Zimmermannova O, Catena X, Rotankova N, Veser C, Rudnik M, Ballocci T, Schärer T, Huang X, Torres MR, Renaud E, Santiago VM, Met Ö, Askmyr D, Lindstedt M, Greiff L, Ligeon LA, Agarkova I, Svane I, Pires C, Rosa F, Pereira CF. In vivo dendritic cell reprogramming for cancer immunotherapy. Science 386, eadn9083 (2024). DOI:10.1126/science.adn9083
Zimmermannova O, Ferreira A, Ascic E, Santiago M, Kurochkin I, Hansen M, Met Ö, Inês Caiado I, Shapiro I, Michaux J, Humbert M, Soto-Cabrera D, Benonisson H, Silvério- Alves R, Gomez-Jimenez D, Bernardo C, Bauden M, Andersson R, Höglund M, Miharada K, Nakamura Y, Hugues S, Greiff L, Lindstedt M, Rosa F, Pires C, Bassani-Sternberg M, Svane I, Pereira CF. Restoring Tumor Immunogenicity with Dendritic Cell Reprogramming. Science Immunology 8, eadd4817 (2023).
Rosa FF, Pires CF, Kurochkin I, Halitzki E, Zahan T, Arh N, Zimmermannová O, Ferreira AG, Li H, Karlsson S, Scheding S, Pereira CF. Single-cell transcriptional profiling informs efficient reprogramming of human somatic cells to cross-presenting dendritic cells. Sci Immunol. 2022 Mar 4;7(69):eabg5539.
Zimmermannova O, Caiado I, Ferreira AG and Pereira C-F (2021) Cell Fate Reprogramming in the Era of Cancer Immunotherapy. Immunol. 12:714822. doi: 10.3389/fimmu.2021.714822
Pires CF, Rosa FF, Kurochkin I and Pereira C-F (2019) Understanding and Modulating Immunity With Cell Reprogramming. Front. Immunol. 10:2809. doi:10.3389/fimmu.2019.02809.
Rosa FF, Pires CF, Kurochkin I, Ferreira AG, Gomes A, Palma LG, Shaiv K, Solanas L, Azenha C, Papatsenko D, Schulz O, Reis e Sousa C, Pereira CF. Direct Reprogramming of Fibroblasts into Antigen-Presenting Dendritic Cells. Science Immunology 2018, 7, 3 (30).

Application
Please email your CV, cover letter and contact information for two references to careers@asgardthx.com to apply. Asgard will review applications on a rolling basis and only shortlisted candidates will be contacted.

Asgard Therapeutics is a spin-off from Lund University, Sweden, aiming to advance cancer immunotherapies by harnessing direct cell fate reprogramming technologies. Our lead program, AT-108, is a adenovirus-based gene therapy that reprograms cancer cells into antigen-presenting dendritic cells, unleashing the immune system against cancer. Asgard is expanding its multidisciplinary team that understands the value and opportunities of working in a startup based in a unique platform technology. We are looking for candidate who are creative and passionate about making a contribution to the cancer immunotherapy field and improve patients’ lives.
Position overview
We are seeking a highly enthusiastic and innovative Scientist/Senior Scientist searching for an opportunity to help building an early-stage company and contribute to the development of next generation cancer immunotherapies.
The successful candidate should have the ability to design experiments autonomously, analyze complex data, troubleshoot technical issues, and supervise junior staff. Strong interpersonal, verbal, and written communication skills are required. Experimental rigor, scientific curiosity, and ability to work in a fast-paced environment, adapting to evolving priorities are musts. The position will be lab-based and research activities will be performed in collaboration with the Cell Reprogramming in Hematopoiesis and Immunity Lab at Lund University (www.pereiralab.com).
Profile
Scientist/Senior Scientist with background in tumor immunology to work in the experimental validation of AT-108. The candidate will focus on both efficacy and safety studies in multiple syngeneic and CDX mouse models. The ideal candidate should have a Ph.D. degree in an immunology-related field with relevant in vitro and in vivo laboratory experience in academia or biotech industry.
Responsibilities
Evaluate efficacy of AT-108 in animal models.
Establish methods to characterize the immune response induced by in vivo cDC1 reprogramming, including multi-color flow cytometry, fluorescence-activated cell sorting, T cell co-culture systems, MHC/peptide tetramer analysis, ELISpot, among other immunoassays.
Design, plan, and execute scientific experiments autonomously to complete program and company goals within designated timelines.
Collect and document primary data to maintain up to date records.
Analyze, summarize data in reports and communicate data to Asgard’s R&D and executive leadership team.

Qualifications:
PhD in Immunology, Cancer Biology, Biology or related field, with 0-5 years of post-graduation experience in academic or industrial environment.
Demonstrated knowledge of cancer immunotherapies, including experience in developing relevant in vivo immuno-oncology models (syngeneic and CDX tumor models) to understand mechanism of action underlying preclinical efficacy of cancer therapies.
Preferred qualifications include a background in dendritic cell biology and expertise in antigen presentation mechanisms, with a favorable consideration for candidates with knowledge in T cell biology.
Experience in the development and application of tumor biology-related in vitro assays, including multi-color flow cytometry for immune profiling, MHC/peptide tetramer, ELISpot and T-cell cytotoxicity assays. Experience with TCR sequencing and MHC peptidomics is a plus.
Felasa B certification.

Literature:
Zimmermannova O, Ferreira A, Ascic E, Santiago M, Kurochkin I, Hansen M, Met Ö, Inês Caiado I, Shapiro I, Michaux J, Humbert M, Soto-Cabrera D, Benonisson H, Silvério- Alves R, Gomez-Jimenez D, Bernardo C, Bauden M, Andersson R, Höglund M, Miharada K, Nakamura Y, Hugues S, Greiff L, Lindstedt M, Rosa F, Pires C, Bassani-Sternberg M, Svane I, Pereira CF. Restoring Tumor Immunogenicity with Dendritic Cell Reprogramming. Science Immunology 8, eadd4817 (2023).
Rosa FF, Pires CF, Kurochkin I, Halitzki E, Zahan T, Arh N, Zimmermannová O, Ferreira AG, Li H, Karlsson S, Scheding S, Pereira CF. Single-cell transcriptional profiling informs efficient reprogramming of human somatic cells to cross-presenting dendritic cells. Sci Immunol. 2022 Mar 4;7(69):eabg5539.
Zimmermannova O, Caiado I, Ferreira AG and Pereira C-F (2021) Cell Fate Reprogramming in the Era of Cancer Immunotherapy. Immunol. 12:714822. doi: 10.3389/fimmu.2021.714822
Pires CF, Rosa FF, Kurochkin I and Pereira C-F (2019) Understanding and Modulating Immunity With Cell Reprogramming. Front. Immunol. 10:2809. doi:10.3389/fimmu.2019.02809.
Rosa FF, Pires CF, Kurochkin I, Ferreira AG, Gomes A, Palma LG, Shaiv K, Solanas L, Azenha C, Papatsenko D, Schulz O, Reis e Sousa C, Pereira CF. Direct Reprogramming of Fibroblasts into Antigen-Presenting Dendritic Cells. Science Immunology 2018, 7, 3 (30).

Application:
Please email your CV, cover letter and contact information for two references to careers@asgardthx.com to apply. Asgard will review applications on a rolling basis and only shortlisted candidates will be contacted.