Lund: Scientist/Senior Scientist In vivo Immuno-Oncology

Redoxis är ett prekliniskt tjänsteföretag inom läkemedelsbranschen. Vi arbetar på uppdrag av andra forskningsföretag och utför forskning på kontraktsbasis med fokus på inflammation och autoimmunitet. Vi söker nu mot bakgrund av ökad efterfrågan på våra tjänster en nya forskare med fokus på in vitro arbete till vårt bolag.
RollenEn betydande del av tiden går till att planera och genomföra prekliniska studier. Du ansvarar för planer, projektmål, tidslinjer, praktiskt utförande, rapportering osv inom projektet. Även litteraturstudier ingår i rollen.
Vi erbjuderRedoxis är under tillväxt och har en lönsam verksamhet med god ekonomi. Vi har som mål att utveckla verksamheten betydligt de kommande åren, för att bli en ännu starkare partner åt både svenska och internationella kunder. Som anställd hos oss får du arbeta i ett litet bolag med stora ambitioner. Du får i stor utsträckning möjlighet att själv forma din tjänst, växa och utvecklas med företaget. 
Din profil och erfarenhetVi söker dig med erfarenhet av prekliniskt arbete och grundläggande förståelse för läkemedelsutveckling. Du ska på självständigt sätt genomföra projekt, implementera nya metoder och vidareutveckla vårt serviceerbjudande. Du kommer arbeta med våra CRO studier och modellutveckling. Du ska kunna driva försök, utföra laborativt arbete praktiskt, analysera data, dra slutsatser och rapportera resultat till både akademiska och industriella partners. Du kommer att ingå i ett av Redoxis team med fokus på in vitro.
Kvalifikationer vi gärna ser att du för med dig:
Erfarenhet av preklinisk forskning, gärna inom inflammation
Erfarenhet av laborativt arbete inklusive metoder som qPCR, ELISA, Flödescytometri och cellodling
Erfarenhet av läkemedelsutveckling
Erfarenhet av projektledning
Goda kunskaper i engelska är ett krav
Goda kunskaper av relevanta dataprogram och Microsoft Office är ett krav

Kompetenser:
Stark förmåga att organisera, planera och genomföra aktiviteter
Ta egna initiativ, arbeta självständigt och fatta beslut
Vara positiv och lösningsinriktad till de utmaningar du ställs inför
Vara flexibel och kunna skifta tempo vid behov, acceptera nya idéer och initiativ
Ta till sig ny information och anpassa sig till den
Tjänsten är förlagd till Redoxis i Lund. Tjänsten är en tillsvidareanställning med 6 månaders provanställning.
AnsökanFör ytterligare information om tjänsten, kontakta VD Malin Hultqvist Hopkins (malin.hultqvist@redoxis.com). Ansökningar behöver vara oss tillhanda senast 14 April 2023. Vi mottar inte ansökningar via epost utan ansök genom att klicka på ”sök tjänst” och ladda upp ditt CV och personliga brev.
Note. We accept applications in both Swedish and English. A nordic language is not mandatory for this position.
Om ossBolaget består idag av 18 heltidsanställda forskare. Vår vision är att bli det bästa tjänstebolaget inom preklinisk inflammation genom vår kompetens, vårt engagemang, vår flexibilitet och vår personliga relation till våra kunder. Redoxis har sin verksamhet vid Medicon Village i Lund, en spännande miljö som bjuder till många interaktioner och samarbeten och bidrar till att även vi som litet företag är del i ett större sammanhang. Redoxis erbjuder anställning i ett bolag som drivs av engagemang och nyfikenhet, med korta beslutsvägar och närvarande ledarskap. Läs mer om Redoxis på www.redoxis.com

Translational Scientist
We are seeking an experienced and highly motivated Scientist for the Translational team at BioInvent in Lund. The Translational team collaborates closely with the Preclinical Development and Clinical Operations Teams, as well as external experts to develop scientifically rigorous translational and exploratory biomarker strategies. These include PD biomarkers for proof-of-mechanism and establishment of early signs of efficacy, as well as predictive biomarkers for patient selection, to help guide clinical development. The team develops PD/PK/ADA/Nab immunoassays and cell-based assays, analyzing pre-clinical and clinical samples, conducting pharmacokinetic evaluations of pre-clinical and clinical data, and monitoring analytical work that is outsourced to CROs and supporting regulatory discussions.
We welcome you to be part of an innovative R&D-driven organization where our primary goal is to develop the next generation immuno-oncology drugs with a focus on improving cancer patient survival and quality of life.
Key responsibilities
The responsibilities of the position include, but are not limited to:
Develop immunoassays and cell-based assays
Analyze pre-clinical (non-GLP) and clinical study samples according to current regulatory guidelines and company procedures
Outline and review study plans and reports
Propose and develop innovative methods and technologies for project development

Professional qualifications
To succeed in this position, we believe you have the following qualifications:
A PhD, or equivalent, with primary focus in either cellular or molecular biology, immunology, cancer biology and/or pharmacology or similar in a relevant field
At least 4 years of industry experience working with biological products
Experience with immunoassay development for PK/PD and ADA/Nab determination
Experience with ELISA/MSD technology
Experience with cell cultures and cell-based assays
Good written and oral communication skills in English

You as a person
As a person, you are thorough, structured, and responsible but at the same time efficient, driven, and creative. Personal suitability is of great importance, and we believe that you have a positive attitude, a strong commitment, flexible are proactive and open minded to take on new challenges. You enjoy communicating and collaborating with others and since you will be working with different projects in parallel. You understand the importance of achieving results, meeting deadlines, and ensuring high quality in your work. You are enthusiastic and enjoy creating results and achieving goals both individually and together with the team.
Location
The position is based in Lund.
Application
Please send your application (CV and personal letter) through our website https://careers.bioinvent.com/
Interviews will be held continuously which means the positions can be filled before deadline. Please make sure to send in your application as soon as possible, at the latest 31 August 2021.


BioInvent has a collective agreement and contact persons for the Unions are: Fredrik Wiberg, Akademikerfo?reningen and Jenny Nilsson, Unionenklubben

About Asgard Therapeutics
Asgard Therapeutics is a privately held biotech company pioneering in vivo direct cell reprogramming for cancer immunotherapy, backed by Johnson & Johnson Innovation – JJDC, Inc., RV Invest, Novo Holdings, Boehringer Ingelheim Venture Fund, and Industrifonden. Our lead candidate, AT-108, is a first-in-class gene therapy that reprograms tumor cells into antigen-presenting dendritic cells (cDC1), triggering a personalized and potent anti-tumor immune response.
Position Overview
We are seeking a Senior Scientist in Bioinformatics and Data Analysis to join our growing research and development team. The ideal candidate will bring deep expertise in computational biology and omics data analysis, with a proven track record of developing and applying bioinformatics workflows to unreval complex biological mechanisms in oncology and immunology. Working at the intersection of bioinformatics and immune oncology, this role will play a pivotal part in the development of novel therapies by integrating multi-omics datasets (e.g., RNA/DNA sequencing, single-cell, spatial, proteomics) to identify biomarkers and support the design and interpretation of preclinical studies. The position requires strong scientific curiosity, independence, and the ability to translate complex datasets into actionable biological insights that advance our research pipeline, inform strategic decision-making, and guide clinical development.
Key responsibilities
Develop, implement, and optimize bioinformatics pipelines and workflows to support drug development efforts, focusing on high-dimensional datasets including bulk and single cell RNA-seq, DNA-seq, spatial transcriptomics, ATAC-seq and proteomics.
Collaborate closely with the internal cross-functional R&D team, collaborators and contractors to support experimental planning and ensure scientific rigor and reproducibility.
Translate complex multi-omics data into actionable biological insights to drive biomarker discovery, elucidate mechanisms of action, and inform clinical strategy.
Lead the interpretation and presentation of bioinformatic findings in a way that is accessible and actionable for both scientific and executive stakeholders.
Stay current with emerging computational tools and advances in immune oncology to integrate novel bioinformatic approaches and pipelines into Asgard’s R&D pipeline.
Oversee bioinformatics data management practices and infrastructure, including data organization, governance, and quality control, to ensure data integrity and traceability throughout the development pipeline.

Qualifications
PhD degree in Bioinformatics, Computational Biology, Systems Biology, Cancer Genomics, Immunology, or a related field.
Expertise in analyzing and integrating complex datasets (e.g. bulk and single-cell RNA-seq with TCR enrichment, spatial transcriptomics, proteomics and ATAC-seq)
Strong programming and data analysis skills in R, Python or similar languages.
Demonstrated ability to deliver independent bioinformatic analyses, from study design through to biological interpretation.
Experience working in oncology, immunology, or translational research.
Proven scientific track record with publications, presentations, or equivalent outputs in bioinformatics-driven discovery or translational pre-clinical and clinical research.
Knowledge of experimental workflows and molecular biology techniques upstream of data generation is a strong plus.
Strong communication and organizational skills, with the ability to work in a collaborative, fast-paced environment.

Literature
Ascic E, at al. In vivo dendritic cell reprogramming for cancer immunotherapy. Science 386, eadn9083 (2024). DOI:10.1126/science.adn9083
Zimmermannova O, et al. Restoring Tumor Immunogenicity with Dendritic Cell Reprogramming. Science Immunology 8, eadd4817 (2023). DOI: 10.1126/sciimmunol.add4817
Rosa FF, et al. Single cell transcriptional profiling informs efficient reprogramming of human somatic cells to cross-presenting dendritic cells. Science Immunology 2022, 7(69). DOI: 10.1126/sciimmunol.abg5539
Rosa F & Pires CF et al. Direct Reprogramming Fibroblasts into Antigen- Presenting Dendritic Cells. Science Immunology. 2018, 7, 3 (30). DOI: 10.1126/sciimmunol.aau4292

Application
Please email your CV, cover letter and contact information for two references to careers@asgardthx.com to apply. Asgard will review applications on a rolling basis and only shortlisted candidates will be contacted.

About Asgard Therapeutics
Asgard Therapeutics is a privately held biotech company pioneering in vivo direct cell reprogramming for cancer immunotherapy, backed by Johnson & Johnson Innovation – JJDC, Inc., RV Invest, Novo Holdings, Boehringer Ingelheim Venture Fund, and Industrifonden. Our lead candidate, AT-108, is a first-in-class gene therapy that reprograms tumor cells into antigen-presenting dendritic cells (cDC1), triggering a personalized and potent anti-tumor immune response.
Position overview
The ideal Senior Scientist Immuno-oncology and Pipeline Development candidate will have a background with expertise in in vivo research and non-viral-based delivery studies. The role will involve executing in vitro and in vivo experiments to support the development of the lead and pipeline programs. Strong interpersonal, verbal, and written communication skills are required. Experimental rigor, scientific curiosity, and the ability to work in a fast-paced environment, adapting to evolving priorities, are a must.
Key responsibilities
Design, plan, and perform in vitro and in vivo experiments to support the development of Asgard’s lead and pipeline programs.
Establish, optimize, and document relevant methods, protocols, and SOPs to support experimental activities.
Serve as internal point of contact for interactions with CDMOs, consultants, and potential collaborators.
Collect, analyze, and document experimental data in a timely and accurate manner.
Communicate results and strategic insights effectively to the R&D and executive leadership team.
Train, mentor, and supervise junior team members as required.

Qualifications:
PhD degree in Immunology, Cancer Biology, Biomedicine, or a related life science discipline.
Hands-on experience with in vivo mouse work in an academic or industry setting.
Basic understanding of cancer immunotherapies is critical, knowledge of dendritic cell and T cell biology is a plus.
Experience in tumor biology-related in vitro assays, including multi-color flow cytometry for ELISpot and T-cell cytotoxicity assays.
Experience in RNA biology and development of RNA-based gene therapy vectors, molecular cloning, vector production, encapsulation in nanoparticles, and in vivo delivery is a plus.
Felasa B or equivalent animal handling certification is required.
Strong organizational skills and ability to work in a team-oriented environment.
Good written and verbal communication skills in English.

Literature
Ascic E, at al. In vivo dendritic cell reprogramming for cancer immunotherapy. Science 386, eadn9083 (2024). DOI:10.1126/science.adn9083
Zimmermannova O, et al. Restoring Tumor Immunogenicity with Dendritic Cell Reprogramming. Science Immunology 8, eadd4817 (2023). DOI: 10.1126/sciimmunol.add4817

Application:
Please email your CV, cover letter and contact information for two references to careers@asgardthx.com to apply. Asgard will review applications on a rolling basis and only shortlisted candidates will be contacted.