Lund: Translational Scientist

About Asgard Therapeutics
Asgard Therapeutics is a privately held biotech company pioneering in vivo direct cell reprogramming for cancer immunotherapy, backed by Johnson & Johnson Innovation – JJDC, Inc., RV Invest, Novo Holdings, Boehringer Ingelheim Venture Fund, and Industrifonden. Our lead candidate, AT-108, is a first-in-class gene therapy that reprograms tumor cells into antigen-presenting dendritic cells (cDC1), triggering a personalized and potent anti-tumor immune response.

Position Overview
The ideal in vivo scientist candidate will have a background in immuno-oncology and hands-on experience in in vivo research. The role will involve executing in vivo and in vitro experiments, analyzing data, troubleshooting technical issues, and contributing to ongoing projects. Strong interpersonal, verbal, and written communication skills are required. Experimental rigor, scientific curiosity, and the ability to work in a fast-paced environment, adapting to evolving priorities, are musts.

Key responsibilities
Conduct in vivo studies using syngeneic and CDX mouse models to evaluate biodistribution, therapeutic efficacy, and safety.
Perform immunological assays including flow cytometry, ELISpot, T-cell co-culture assays, and cytokine profiling.
Analyze and summarize data in reports and communicate findings to Asgard's R&D and executive leadership team.
Assist in experiment planning, execution, and documentation according to standard protocols.


Qualifications
PhD degree in Immunology, Cancer Biology, Biomedicine, or a related life science discipline.
Hands-on experience with in vivo mouse work in an academic or industry setting.
Basic understanding of cancer immunotherapies is critical, knowledge of dendritic cell and T cell biology is a plus.
Experience in tumor biology-related in vitro assays, including multi-color flow cytometry for ELISpot and T-cell cytotoxicity assays.
Experience with small molecule and viral vectors handling and their in vivo administration is a plus.
Felasa B or equivalent animal handling certification is required.
Strong organizational skills and ability to work in a team-oriented environment.
Good written and verbal communication skills in English.


Literature
Ascic E, at al. In vivo dendritic cell reprogramming for cancer immunotherapy. Science 386, eadn9083 (2024). DOI:10.1126/science.adn9083
Zimmermannova O, et al. Restoring Tumor Immunogenicity with Dendritic Cell Reprogramming. Science Immunology 8, eadd4817 (2023). DOI: 10.1126/sciimmunol.add4817


Application
Please email your CV, cover letter and contact information for two references to careers@asgardthx.com to apply. Asgard will review applications on a rolling basis and only shortlisted candidates will be contacted.

About the position
Are you Idogen’s next Senior Research Scientist? Do you have expertise and experience in Immunology/transplantation immunology/ human cell biology?

Would you like to apply your expertise in a company that pushes the boundaries of science and turns ideas into life changing therapies? Join Idogen and become a key player in leading, designing, and conducting R&D projects within the immunology area.

Idogen develops tolerogenic cell therapies to prevent the patient’s immune system from attacking biological agents, transplanted organs or the body’s own cells or tissues. The company is on a growth journey and has in March 2022 received Swedish MPA approval to start a Clinical Trial within the indication Hemophilia A.

As a Sr. Scientist you will be part of the R&D team of 9 people, reporting to the Chief Scientific Officer.

Responsibilities
• Lead, design, and conduct research and development projects within the immunology area
• Plan, perform, and report experiments, including primary cell purification and cultures, cell- based assays and multicolour flow cytometry-based and Luminex immunophenotyping
• Work closely with CRO within non-clinical area
• Actively apply knowledge gained from literature, conferences and previous working experience on novel concept and assay development

Your profile
• Ph.D. within immunology, preferably within transplantation
• Work experience in related scientific discipline and/or Post Doc. experiences
• Experience in being the lead of a project team, from research to development phase, and preferably clinical phase
• Expertise in a wide range of cell-based assays, including primary cell purification and cultures and multicolour flow cytometry
• Experienced in working according to GxP and EMA/FDA guidelines
• Ability to independently design, coordinate, perform, analyse, and report experiments, always with quality in mind
• Ability to conduct in vivo studies and experiences to work with CROs
• Excellent communication skills, both orally and in writing
• As a person you are highly motivated, quality minded and enjoy working in a team-oriented environment
• Cell therapy experience from a small start-up company is a merit

About the organisation
Idogen is a Swedish biotechnology company based in Lund, listed on the Nasdaq First North Growth Market. Idogen revolutionises the treatment of several disorders in which the body’s immune system does not function as it should, and for which there is a major unmet medical need – such as in autoimmune diseases, organ transplant rejection and in patients who have developed anti-drug antibodies.

QRIOS Life Science & Engineering is supporting Idogen on this recruitment. We are a recruitment and consulting company that is strongly inspired by those who never stop looking for new solutions. As we say, QRIOS MINDS GO FURTHER

We are interviewing candidates on an ongoing basis and welcome your application via the application link today.

BioInvent ‘s activity spans all aspects of drug development, from discovery, preclinical and translational research, to manufacturing and clinical development.

Together we are creating the exciting future of BioInvent, and we welcome you to be part of it – as our

Bioinformatics Research Scientist

We are seeking an experienced and highly motivated Bioinformatics Research Scientist for the Computational Biology team at BioInvent in Lund.
We welcome you to join an innovative R&D-driven organization. Our primary goal is to develop the next generation of immuno-oncology drugs, focusing on improving cancer patient survival and quality of life.

Key Responsibilities

Analyze and process internally generated single-cell and spatial transcriptomics/ multi-omics datasets and integrate publicly available data to generate meaningful biological insights.

Collaborate closely with cross-functional teams and apply expertise in bioinformatics to integrate data types to drive innovative projects

Employ state-of-the-art machine learning and AI techniques to uncover patterns in extensive biological datasets, developing predictive models to identify biomarkers


Your Qualifications

To succeed in this position, we believe you have the following qualifications:
PhD degree in Bioinformatics, Computational Biology, or related disciplines
Previous working experience in multi-omics data analysis (eg. genetics / genomics, bulk, single-cell transcriptomics, spatial transcriptomics, proteomics etc.)
Proficient in R and/or Python, Unix/Bash
Proficiency in machine learning and AI methodologies for analyzing large-scale biological data and developing ML models to predict biomarkers
Familiarity with high-performance computing and cloud-based computing (preferably AWS) environments is a plus
Demonstrated success in academic or industry settings, as evidenced by a strong publication record
Strong problem-solving skills and ability to work in a collaborative environment



You, as a person

As a person, you are thorough, structured, responsible but also efficient, driven, and creative. Personal suitability is of great importance, and we believe that you have a positive attitude and a strong commitment and are flexible, proactive, and open-minded to take on new challenges. You understand the importance of achieving results, meeting deadlines, and ensuring high quality in your work. You are enthusiastic and enjoy creating results and achieving goals individually and with the team.
Location
The position is based in Lund.
Application
Please send your application (CV and personal letter) and tell us why you are the right person for this position. Please make sure to send in your application, 31st of January 2025 at the latest.

The BioInvent team covers all aspects of drug development, including discovery, preclinical and translational research, manufacturing, and clinical development. Together we are creating the exciting future of BioInvent, and we welcome you to our Clinical Development Team.

Safety Scientist –
Safety and Pharmacovigilance
The global safety scientist role is responsible for providing scientific expertise to safety surveillance and risk management activities for BioInvent products in clinical development. The role actively supports the BioInvent Safety and Pharmacovigilance function and closely collaborates with the Safety Physician and Medical Directors.
This role also provides support to BioInvent Medical Directors e.g. review the safety data in the clinical database and raise queries as required, participate in investigator calls/meetings, and support preparation of safety material for scientific meetings.
Key responsibilities
Perform signal detection activities
Participate in periodic safety data review meetings, support the medical director in preparation of material, and coordinates the meetings
Support/Lead DSUR and PSLL development or oversee the vendor preparing the DSURs/PSLLs and contribute to the risk evaluation and benefit-risk assessment
Contribute to study document development e.g. study protocol and IB
Provide support to Safety operations as required e.g. SAE management and reconciliation, vendor management and compliance monitoring
Participate and provide support in Audits and Inspections
Support the Medical Director in review and assessment of clinical safety data
Support MedDRA coding review as required
Proactively contribute to process improvement activities
Maintain a central repository of drug safety documents, including records of signal detection and other PV activities pertinent to regulatory inspections
Support oversight of CRO Medical Monitoring and Safety activities to ensure appropriate and timely handling of safety issues
Close collaboration with other functional areas to achieve business goals and objectives

Requirements
To succeed in this role, you have, at least, a bachelor’s degree in life sciences/pharmacy/nursing degree. You need to have four or more years of clinical drug development experience in the biopharmaceutical industry or a related sector (e.g. academia; CRO; etc). Preferably including 2-3 years of experience in a clinical drug safety related role, ideally in early development.
Other requirements are
Good knowledge of international pharmacovigilance requirements, specifically in Europe and US
Good understanding of ICH-GCP
Experience in safety signal detection activities
Previous experience in DSUR preparation, writing and/or review

· Understanding of the MedDRA and use of safety databases for adverse event evaluation and reporting
Experience working with vendor teams and providing oversight of outsourced safety activities
Ability to prioritise and handle projects simultaneously
Prior therapeutic experience in oncology would be an advantage
Strong presentation skills, effective at summarizing and presenting the key considerations and decision points
Proficient in written and spoken English
Literature review experience is beneficial

Personal suitability is of great importance. You are efficient, have a strong commitment and ability to make things happen. You understand the importance of achieving results, keeping deadlines while securing high quality deliverables. You are enthusiastic, a kind person and enjoy creating results and achieving goals both individually and together with your teams.
The company is in Lund, Sweden. However, relocation is not a requirement for European residents.
BioInvent is in a unique situation with a great potential to change the future. If this is your profile and would like to contribute to change the way cancer is treated today, you are welcome to apply for the position, we want to hear from you!
Please send us your application, personal letter and CV and tell us why you are the right person for this position, at the latest the 28th of October 20204. Interviews will be held continuously which means the positions can be filled before deadline.

BioInvent ‘s activity spans all aspects of drug development, from discovery, preclinical and translational research, to manufacturing and clinical development.

Together we are creating the exciting future of BioInvent, and we welcome you to be part of it – as our
Translational Principal Scientist
We are seeking an experienced and highly motivated Senior Scientist for the Translational team at BioInvent in Lund. The Translational team collaborates closely with the Preclinical Research and Clinical Development Teams and external experts to develop scientifically rigorous translational and exploratory biomarker strategies. These include PD biomarkers for proof-of-mechanism and establishment of early signs of efficacy and predictive biomarkers for patient selection to help guide clinical development. The team develops PD/PK/ADA/Nab immunoassays, cell-based assays, and multiplex histo-assays to analyze pre-clinical and clinical samples. It also monitors analytical work outsourced to CROs and supports regulatory discussions.
We welcome you to join an innovative R&D-driven organization. Our primary goal is to develop the next generation of immuno-oncology drugs, focusing on improving cancer patient survival and quality of life.
Key responsibilities
The responsibilities of the position include, but are not limited to:
· Review, analyze, and summarize PD and biomarker data from ongoing clinical studies
· Keeping up with the state-of-the-art biomarkers, technologies, and study designs to support our clinical development programs
· Propose and develop innovative methods and technologies for the generation of PD biomarkers, proof-of-mechanism, and efficacy data in our clinical development programs
· Outline, write and review study plans and reports
Professional qualifications
To succeed in this position, we believe you have the following qualifications:
· A PhD, or equivalent, with a primary focus in either cellular or molecular biology, immunology, cancer biology, and/or pharmacology or similar in a relevant field
· At least 10 years post-doc experience of which at least 5 years of industry experience working with biological products
· Good written and oral communication skills in English
You, as a person
As a person, you are thorough, structured, responsible but also efficient, driven, and creative. Personal suitability is of great importance, and we believe that you have a positive attitude and a strong commitment and are flexible, proactive, and open-minded to take on new challenges. You enjoy communicating and collaborating with others since you will work on different projects in parallel. You understand the importance of achieving results, meeting deadlines, and ensuring high quality in your work. You are enthusiastic and enjoy creating results and achieving goals individually and with the team.
Location
The position is based in Lund.
Application
Please send your application (CV and personal letter) and tell us why yare the right person for this position. Interviews will be held continuously which means the positions can be filled before the deadline. Please make sure to send in your application as soon as possible, at the latest 26 August 2024.